Manure is often viewed by many as an environmental liability. However, if manure is applied at rates equal to or less than the nitrogen (N) requirement of a crop, can manure produce environmental benefits over commercial fertilizer? This was the focus of an Asian research group which summarized the results of 141 published studies from Asia, Europe, and the U.S. comparing manure substitution for fertilizer. This article summarizes the “Take Home Messages” from this research paper.